SAM-e stands for S-adenosylmethionine, and it is an amino acid which is developed from combining methionine and adenosine triphosphate, or ATP. SAM-e is made in the liver, and the production of it can be affected by prescription and over-the-counter drugs smf alcohol, which are all hard on the liver. Lowered production of SAM-e is beginning to be linked to diseases including depression and osteoarthritis. SAM-e has been used for two decades in Europe as a natural anti-depressant, When SAM-e is low in the body, less serotonin and dopamine is produced -- these are neurotransmitters connected to mood. While much more research needs to be done, early results show that SAM-e appears to be comparable to state-of-the-art treatments for depression without having significant side effects.